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Dronabinol has a modest but obvious and clinically relevant analgesic effect on central pain in sufferers with multiple sclerosis and really should be available for individuals whose central pain is not sufficiently treated with alternate medicines, conclude the authors.. Cannabis extract helps reduce pain in multiple sclerosis patients Does the cannabinoid dronabinol reduce central discomfort in multiple sclerosis? Randomised double blind placebo managed crossover trial, BMJ Online First. The cannabis extract, dronabinol, decreases pain in sufferers with multiple sclerosis, finds new research published on bmj.com today.